Inhibition of interleukins 17A and 17F in psoriatic arthritis
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Abstract
Psoriasis is the most common chronic inflammatory skin disease; 15–30% of patients with psoriasis have psoriatic arthritis.1 The interleukin (IL) 23 and IL17 pathway has a crucial role in pathogenesis, and inhibitors of the IL17 pathway have rewritten treatment paradigms especially for psoriasis control, with up to 50% of patients achieving at least 100% reductions in Psoriasis Area and Severity Index (PASI) scores (PASI100).2 Before IL17 inhibitors were introduced, around 60% of patients achieving a 75% reduction in PASI scores was the best outcome that could be expected.
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The Lancet
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395
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10222
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Biomedical and clinical sciences
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Nash, P, Inhibition of interleukins 17A and 17F in psoriatic arthritis, The Lancet, 2020, 395 (10222), pp. 395-396