To produce a high quality article for physicians that reviews the current literature pertaining to NOAC's, in particular, their use in clinical practice, known drug interactions and side effect profile. Medline, Cochrane and PubMed databases were searched for the most recent and clinically sound articles pertaining apixaban, rivaroxaban and dabigatran. Researchers found the trials for each of these NOAC's to be sound and have results that can be translated into clinical practice.