This article provides a synthesis of the Middle Pleistocene hominin record of West Iberia, which comprises sites displaying abundant concentrations of large flake Acheulean (LFA) assemblages, as well as isolated examples of Early Middle Palaeolithic (EMP) technology. These sites typically have age ranges spanning marine isotopic stages (MIS) 11–6, within the second half of the Middle Pleistocene, and are primarily located in fluvial environments related to the main regional river basins. The LFA sites display extensive occurrences of handaxes and cleavers on flake blanks (detached from large cores), with a large number of knapping remains, such as flakes or small-medium cores, showing simple reduction patterns. Over the identified age range of these sites, especially during the MIS 9–6 interval, we observe constant technological stability, without strong variations over time, and independent of the functionality of individual sites. These fixed technological and behavioural patterns reinforce the African affinities of the southwestern European Acheulean, in contrast to Acheulean assemblages identified in the northernmost areas of Europe.