This study proposes a sampled‐data design method for robust control of open two‐level quantum systems with operator errors. The required control performance is characterised using the concept of a sliding mode domain related to fidelity, coherence or purity. The authors have designed a control law offline and then utilise it online for a two‐level system subject to decoherence with operator errors in the system model. They analyse three cases of approximate amplitude damping decoherence, approximate phase damping decoherence and approximate depolarising decoherence. They design specific sampling periods for these cases that can guarantee the required control performance.