Background: In December 2019, the spread of a new infectious disease was reported in Wuhan, caused by a new coronavirus named COVID-19 by the World Health Organization. This study aims to compare the dispersion of COVID-19 disease among four Iranian cities in North Khorasan named Bojnord, Farooj, Jajarm, and Shirvan. Materials and Methods: This cross-sectional study includes information about the daily morbidity and mortality of COVID-19 in 1124 patients from March to May 2021. The analysis of variance method, Scheffe post hoc technique and Leven’s test are used to compare the means and the variances of daily morbidity and mortality of these cities. Finally, the coefficients of variation (CVs) of the morbidity and mortality are compared. Results: The means of daily morbidity in Bojnord, Farooj, Jajarm, and Shirvan cities are 6.387, 0.946, 1.150, and 2.193, respectively. Furthermore, the means of daily mortality in Bajnourd, Farooj, Jajarm, and Shirvan are 0.763, 0.193, 0.161, and 0.290, respectively. The means and the variances of both daily mortality and morbidity are significantly different in all four cities (P < 0.05). Furthermore, CVs of daily morbidity in the cities of Bojnord, Farooj, Jajarm, and Shirvan are 0.665, 1.026, 1.032, and 0.787, respectively. The CVs of daily mortality in these cities are 1.196, 2.052, 2.468, and 1.728, respectively. The CVs of both daily mortality and morbidity are significantly different in all four cities (P < 0.05). Conclusion: The ratio of CVs is a good option for comparing the spread of COVID-19 in different regions with different means and variances.