Effects of magnetic field strength and particle aggregation on relaxivity of ultra-small dual contrast iron oxide nanoparticles
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Li, Zhen
Wu, Yuao
Cowin, Gary
Zhang, Shaohua
Yago, Anya
Whittaker, Andrew K
Xu, Zhi Ping
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Abstract
This study aims to compare the relaxivities of ultra-small dual positive and negative contrast iron oxide nanoparticles (DCION) at different magnetic field strengths ranging from 4.7 to 16.4 T at physiological temperatures; and to investigate the effect of particle aggregation on relaxivities. Relaxivities of DCIONs were determined by magnetic resonance imaging scanners at 4.7, 7, 9.4, and 16.4 T. Both longitudinal (T 1) and transverse relaxation times (T 2) were measured by appropriate spin-echo sequences. It has been found that both longitudinal and transverse relaxivities are significantly dependent on the magnetic field strength. Particle aggregation also strongly affects the relaxivities. Awareness of the field strength and particle colloid stability is crucial for the comparison and evaluation of relaxivity values of these ultra-small iron oxide nanoparticles, and also for their medical applications as contrast agents.
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Materials Research Express
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4
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11
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Materials engineering
Condensed matter physics
Science & Technology
Technology
Materials Science, Multidisciplinary
Materials Science
dual contrast iron oxide nanoparticle
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Ta, HT; Li, Z; Wu, Y; Cowin, G; Zhang, S; Yago, A; Whittaker, AK; Xu, ZP, Effects of magnetic field strength and particle aggregation on relaxivity of ultra-small dual contrast iron oxide nanoparticles, Materials Research Express, 2017, 4 (11)