Australian clinical practice guidelines for the diagnosis and management of Barrett's Esophagus and Early Esophageal Adenocarcinoma

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Whiteman, David C
Appleyard, Mark
Bahin, Farzan F
Bobryshev, Yuri V
Bourke, Michael J
Brown, Ian
Chung, Adrian
Clouston, Andrew
Dickins, Emma
Emery, Jon
Eslick, Guy D
Gordon, Louisa G
Grimpen, Florian
Hebbard, Geoff
Holliday, Laura
Hourigan, Luke F
Kendall, Bradley J
Lee, Eric YT
Levert-Mignon, Angelique
Lord, Reginald V
Lord, Sarah J
Maule, Derek
Moss, Alan
Norton, Ian
Olver, Ian
Pavey, Darren
Raftopoulos, Spiro
Rajendra, Shan
Schoeman, Mark
Singh, Rajvinder
Sitas, Freddy
Smithers, B Mark
Taylor, Andrew C
Thomas, Melissa L
Thomson, Iain
To, Henry
von Dincklage, Jutta
Vuletich, Christine
Watson, David I
Yusoff, Ian F
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Barrett's esophagus (BE), a common condition, is the only known precursor to esophageal adenocarcinoma (EAC). There is uncertainty about the best way to manage BE as most people with BE never develop EAC and most patients diagnosed with EAC have no preceding diagnosis of BE. Moreover, there have been recent advances in knowledge and practice about the management of BE and early EAC. To aid clinical decision making in this rapidly moving field, Cancer Council Australia convened an expert working party to identify pertinent clinical questions. The questions covered a wide range of topics including endoscopic and histological definitions of BE and early EAC; prevalence, incidence, natural history, and risk factors for BE; and methods for managing BE and early EAC. The latter considered modification of lifestyle factors; screening and surveillance strategies; and medical, endoscopic, and surgical interventions. To answer each question, the working party systematically reviewed the literature and developed a set of recommendations through consensus. Evidence underpinning each recommendation was rated according to quality and applicability.

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Journal of Gastroenterology and Hepatology

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© 2015 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing Asia Pty Ltd. This is the peer reviewed version of the following article: Australian clinical practice guidelines for the diagnosis and management of Barrett's Esophagus and Early Esophageal Adenocarcinoma, Journal of Gastroenterology and Hepatology, Volume30, Issue5, May 2015, Pages 804-820, which has been published in final form at 10.1111/jgh.12913 . This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving (

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