Resilience engineering has changed the value of expertise from meeting required standards, to how it helps organizations to adapt. This chapter discusses the origin of the concept of resilience and how it has been applied to sociotechnical systems within the safety domain. From there we review the current literature to explore how to manage expertise, considering both its possible good and bad effects, to engineer resilience into organizations. For this, the chapter looks at how this applies separately to frontline workers, teams and management, and on a systems level. While expertise generally has a positive relation to resilience on all levels, how to two relate to each other does change. This affects how expertise is best managed at different levels of an organization.