Marine debris poses considerable threat to biodiversity and ecosystems and has been identified as a stressor for a variety of marine life. Here we present results from the first study quantifying the amount and type of debris accumulation in Maui leeward waters and relate this to cetacean distribution to identify areas where marine debris may present a higher threat. Transect surveys were conducted within the 4-island region of Maui, Hawai'i from April 1, 2013 to April 15, 2016. Debris was found in all areas of the study region with higher concentrations observed where the Au'au, Kealaikahiki, and Alalakeiki channels converge. The degree of overlap between debris and cetaceans varied among species but was largest for humpback whales, which account for the largest portion of reported entanglements in the 4-island region of Maui. Identifying areas of high debris-cetacean density overlap can facilitate species management and debris removal efforts.