Aim/Introduction: The aim of this study was to optimize pelvic 90’ delayed acquisition with [68]Ga-PSMA PET/CT using CT images acquired at 60’, in order to reduce time and adsorbed dose as compared to delayed acquisition with a second CT. Materials and Methods: High-risk prostate cancer patients have been enrolled and scanned with [68Ga]Ga-PSMA-PET/CT on a PET/CT GE Discovery MI (GE Healthcare, Little Chalfont, United States). Automatic dose modulation was applied with a tube voltage of 100 kV, 15 - 400 mA, noise Index 12, thickness 3.75, pitch 1,375 and collimation 40mm. Standard 8-bed acquisition was performed 60’ post-injection and after voiding, while pelvic delayed acquisition after 90’ and repeated voiding, with 3-beds acquisition. Before first scan, laser triangulation on iliac crests has been performed in order to mark the intersection on the skin of the patient and to collect the bed position. Before delayed acquisition, patient precise re-positioning has been performed. Delayed images acquisition has been reconstructed with previous standard CT images. Acquisition time were recorded. Adsorbed dose was calculated by using these parameters: • CTDIvol (Computed Tomography Dose Index) measured in mGy, represents an approximation to the average absorbed dose in dosimetric acrylic phantom from helical CT scan. • DLP (Dose Length Product) measured in mGy/cm, defined as total energy absorbed by a scan volume. DLP is calculated CTDIvol*L, where L represents the length of scan. Data were compared to a group of 10 patients with 60’ and 90’ PSMA-PET/CT acquisition according to standard protocol. Results: Overall 10 patients have been included, median aged 68- year old. PSMA PET-CT was positive in 9 cases. We did not observe any change in number or detection rate between 60’ and 90’ images (11 lesions within the prostate gland, 2 lymph node metastasis), while PSMA uptake increased in 7/11 prostate lesions. Median CTDIvol and DLP values were 62% lower as compared to standard protocol (8.97 mGy and 1016.49 mGy/cm vs. 23.29 mGy and 1556.69 mGy/cm, respectively). The mean time to re-scan the patients was 42’ versus 60’, with a 30% of time reduction. Conclusion: The proposed 90’ pelvic delayed reduces the adsorbed dose to patient by avoiding a second CT acquisition, with comparable detection rate as compared to standard protocol. Moreover, this procedure significantly reduces the time for delayed acquisition, thus improving the patient’s management.