The Genetics of Androgen Receptor Signalling in Male Fertility
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Smith, LB
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Abstract
The androgen testosterone has an essential trophic role in the development of male physiology and in adult spermatogenesis and fertility. Testosterone mainly exerts its effect through the androgen receptor (AR), a ligand-Activated transcription factor that is activated by binding the androgens testosterone or dihydrotestosterone. Mutations in AR can result in the genetic disorder androgen insensitivity syndrome, which results in a feminised phenotype and developmental problems, including cryptorchidism and disrupted spermatogenesis, thus complicating the investigation of the role of AR in adulthood. Transgenic mouse models of conditional AR inactivation have helped to define cell-specific roles for AR in the testis and the wider male reproductive system, and revealed a complex paracrine signalling network that controls fertility through several cell types and differing mechanisms.
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Monographs in Human Genetics
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21
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Biological sciences
Genetics
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O'Hara, L; Smith, LB, The Genetics of Androgen Receptor Signalling in Male Fertility, Monographs in Human Genetics, 2017, 21, pp. 86-100