Role of thioredoxin-1 in apoptosis induction by α-tocopheryl succinate and TNF-related apoptosis-inducing ligand in mesothelioma cells

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Freeman, Ruth E
Neuzil, Jiri
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2006
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Abstract

Malignant mesothelioma (MM) is a fatal type of cancer. We studied the role of the redox-active protein thioredoxin-1 (Trx-1) in apoptosis induced in MM cells and their non-malignant counterparts (Met-5A) by a-tocopheryl succinate (a-TOS) and TNF-related apoptosis-inducing ligand (TRAIL). MM cells were susceptible to a-TOS and less to TRAIL, while Met-5A cells were susceptible to TRAIL and resistant to a-TOS. MM cells expressed very low level of the Trx-1 protein, which was high in Met-5A cells, while the level of Trx-1 mRNA was similar in all cell lines. Downregulation of Trx-1 further sensitised Met-5A cells to TRAIL but not to a-TOS. Our data suggest that the role of Trx-1 in apoptosis modulation is unrelated to its anti-oxidant properties.

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FEBS Letters

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580

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11

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© 2006 Elsevier. Please refer to the journal's website for access to the definitive, published version.

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Medicinal and biomolecular chemistry

Biochemistry and cell biology

Evolutionary biology

Cancer cell biology

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