Response: Value and Timing of Repeat Spirometry or FENO in Children With Asthma Remains Unclear

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Fielding, Shona
Pijnenburg, Marielle
de Jongste, Johan C
Pike, Katharine C
Roberts, Graham
Petsky, Helen
Chang, Anne B
Fritsch, Maria
Frischer, Thomas
Szefler, Stanley
Gergen, Peter
Vermeulen, Francoise
Vael, Robin
Turner, Steve
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2019
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To the Editor: We thank Drs Yawn and Kaplan for their interest and comments on our article in which we describe a secondary analysis of data from seven published trials where fractional exhaled nitric oxide (Feno) was used to guide asthma treatment in children.1 We believe that our results offer relevance to clinicians attempting to interpret repeated measurements of spirometry and Feno. To the best of our knowledge, our analysis is the first to: (1) compare the clinical outcomes following a change in FEV1 and Feno over time; (2) compare clinical outcomes following absolute vs percent change in Feno; and (3) describe clinical outcomes following changes in FEV1 that fall within the range of “normal.”

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Chest

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155

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6

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© 2019 American College of Chest Physicians. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence, which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.

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Clinical sciences

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Life Sciences & Biomedicine

Critical Care Medicine

Respiratory System

General & Internal Medicine

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Fielding, S; Pijnenburg, M; de Jongste, JC; Pike, KC; Roberts, G; Petsky, H; Chang, AB; Fritsch, M; Frischer, T; Szefler, S; Gergen, P; Vermeulen, F; Vael, R; Turner, S, Value and Timing of Repeat Spirometry or FENO in Children With Asthma Remains Unclear Response, Chest, 2019, 155 (6), pp. 1313-1314

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