Cubyl amides: Novel P2X7 receptor antagonists
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Author(s)
Gunosewoyo, Hendra
Guo, Jun Liu
Bennett, Maxwell R
Coster, Mark J
Kassiou, Michael
Guo, Jun Liu
Bennett, Maxwell R
Coster, Mark J
Kassiou, Michael
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Dr. D L Boger, L Ghosez, M. Shibasaki
Date
2008
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Abstract
Polycyclic amides 2 and 5-9 were successfully synthesised and their lipophilicity profiles were evaluated using reverse-phase HPLC. All synthesised compounds possessed P2X7R antagonistic properties when tested on rat spinal cord microglia cells. Extensive screening for binding to other neuroreceptor subtypes demonstrated their P2X7 selectivity.
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Bioorganic & Medicinal Chemistry Letters
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18
Issue
13
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Subject
Medicinal and biomolecular chemistry
Organic chemistry
Pharmacology and pharmaceutical sciences