Chemical constituents from Sophora tonkinensis and their glucose transporter 4 translocation activities
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Deng, Shihao
Huang, Mi
Wang, Jialin
Chen, Li
Xiong, Mingrui
Yang, Jie
Zheng, Sijiang
Ma, Xinhua
Zhao, Ping
Feng, Yunjiang
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Abstract
Bioassay-guided phytochemical investigation of the EtOAc fraction (ST-EtOAc) from the roots of Sophora tonkinensis resulted in the isolation of a new compound 6aR,11aR-1-hydroxy-4-isoprenyl-maackiain (1), along with 12 known compounds (2–13). The structure of the new compound was established by 1D and 2D NMR, MS data and circular dichroism analysis. Polyprenylated flavonoids 6–9 and 11–13 increased GLUT-4 translocation by the range of 1.35–2.75 folds. Sophoranone (8) exerted the strongest activity with 2.75 folds GLUT-4 translocation enhancement at the concentration of 10 μM. This is the first report of the GLUT-4 translocation activity of the plant Sophora tonkinensis.
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Bioorganic & Medicinal Chemistry Letters
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27
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6
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© 2017 Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence (http://creativecommons.org/licenses/by-nc-nd/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
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Medicinal and biomolecular chemistry
Organic chemistry
Biochemistry and cell biology not elsewhere classified
Pharmacology and pharmaceutical sciences