Aim The purpose of this study is to carry out a three-year retrospective study on the use of autologous Concentrated Growth Factor (CGF) on dental patients undergoing oral regenerative treatment. Materials and methods Data was gathered from 46 patients who received oral regenerative therapy using CGF within the last three years in a private dental clinic. CGF mixture of demineralized freeze-dried bone (DFDB sticky bone) and fibrin membrane was obtained from the patient’s centrifuged blood. Patient medical history, demographic details, social habits, vital signs, oral hygiene status, digital radiographs, clinical observation and photos, survival rate as well as numeric pain intensity scale and visual analogue satisfaction scale were used to evaluate the clinical outcomes. Results and discussion All patients had uneventful outcomes in terms of wound healing complications and satisfaction. No patients reported of failure. Though factors like smoking, poor oral hygiene status, periodontitis, and medical conditions such as diabetes have been recognized in the literature, they had no statistical significance in this study. However, gender and age showed statistical significance with the following variables: more males with SDB than females; more older patients (>50 years old) with SDB and high blood than those under 50. Conclusion Using the limited patient data available in the last three years in this study, it was found that CGF is a novel approach for regeneration of defective oral tissues, especially in males and older patients with SDB and high blood pressure. Furthermore, CGF renders good outcomes in terms of uneventful wound healing, biocompatibility, minimal pain, and high satisfaction rate.