Mitochondrial DNA haplogroups J and K are not protective for Parkinson's disease in the Australian community

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Mehta, Prachi
Mellick, George D
Rowe, Dominic B
Halliday, Glenda M
Jones, Michael M
Manwaring, Neil
Vandebona, Himeslla
Silbum, Peter A
Wang, Jie Jin
Mitchell, Paul
Sue, Carolyn M
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2009
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Abstract

MtDNA haplogroups J and K have been associated with a decreased risk of developing Parkinson's disease (PD). To confirm this finding, we compared the distribution of mtDNA haplogroups J and K in a large sample of Australian patients with PD (n = 890) to population-based controls (n = 3,491). We assigned subjects to haplogroups J or K using standard PCR/RFLP techniques. Of the 890 subjects with PD, 10.6% were haplogroup J (95% CI 8.6-12.8, n = 94) and 7.1% were haplogroup K (95% CI 5.5-8.9, n = 63). In our controls, 10.2% belonged to haplogroup J (95% CI 9.2-11.2, n = 356), and 7.8% were in haplogroup K (95% CI 6.9-8.7, n = 272). There was no significant difference in the prevalence of mtDNA haplogroup J or K in PD patients compared to population-based controls. Our findings indicate that mtDNA haplogroups J and K are not associated with a lower risk of PD.

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Movement Disorders

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24

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2

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© 2009 Movement Disorders Society. Published by John Wiley & Sons, Ltd. Self-archiving of the author-manuscript version is not yet supported by the Movement Disorders Society. Please refer to the journal link for access to the definitive, published version or contact the authors for more information.

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Clinical sciences

Sports science and exercise

Neurosciences

Neurology and neuromuscular diseases

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