Efficacy of GBT440 to Left-Shift the Oxy-Hemoglobin Dissociation Curve in Healthy Individuals and Preserve Arterial Saturation During Submaximal Hypoxic Exercise
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Cross, T
Chase, S
Joyner, M
Curry, T
Isautier, J
Lehrer, J
Vlahakis, NE
Johnson, BD
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San Diego, CA, USA
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Introduction: Numerous conditions can cause hypoxia-induced cardiopulmonary perturbations that are associated with the degree of arterial oxygen desaturation. Global Blood Therapeutics (GBT) has developed an allosteric modulator of hemoglobin (GBT440) that increases the affinity of hemoglobin for oxygen and left shifts the oxy-hemoglobin dissociation curve. Accordingly, this study investigated the efficacy of GBT440 to preserve arterial oxygen saturation while exercising during acute hypoxia.
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American Journal of Respiratory and Critical Care Medicine
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197
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Biomedical and clinical sciences
Cardiovascular medicine and haematology
Clinical sciences
Science & Technology
Life Sciences & Biomedicine
Critical Care Medicine
Respiratory System
General & Internal Medicine
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Stewart, G; Cross, T; Chase, S; Joyner, M; Curry, T; Isautier, J; Lehrer, J; Vlahakis, NE; Johnson, BD, Efficacy of GBT440 to Left-Shift the Oxy-Hemoglobin Dissociation Curve in Healthy Individuals and Preserve Arterial Saturation During Submaximal Hypoxic Exercise, American Journal of Respiratory and Critical Care Medicine, 2018, 197