Polydiscamides B–D from a Marine Sponge Ircinia sp. as Potent Human Sensory Neuron-Specific G Protein Coupled Receptor Agonists
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Carroll, Anthony R
Pass, David M
Archbold, Julia K
Avery, Vicky M
Quinn, Ronald J
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Abstract
Polydiscamides B, C, and D (1-3) were isolated from a sponge Ircinia sp. The structures of 1 to 3 were elucidated by the comparison of their NMR and HRESIMS spectroscopic data with that of a structurally related compound, polydiscamide A. All compounds showed potent agonist activity against human sensory neuron-specific G protein couple receptor (SNSR), a receptor involved in the modulation of pain, and they are the first examples of nonendogenous human SNSR agonists.
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Journal of Natural Products
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71
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1
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© 2008 American Chemical Society. Self-archiving of the author-manuscript version is not yet supported by this publisher. Please refer to the journal link for access to the definitive, published version or contact the authors for more information.
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Chemical sciences
Biological sciences
Biomedical and clinical sciences
Traditional, complementary and integrative medicine