Culture can be defined as shared values and behavior patterns and is highly relevant for the development of socio-technical systems. Publications in this domain show substantial heterogeneity due to the variety of related problems and questions, as well as the focus on different types of culture. In this paper we develop a comprehensive framework for the design of culturally sensitive information systems that enables us to structure previous publications. Based on this framework, a literature review is conducted to investigate which meeting points of national culture and the elements of system development have thus far been addressed.We explore existing knowledge related to the different aspects of culturally sensitive design of information systems and identify areas where further research is needed in order to enhance corresponding design knowledge.