Bivalirudin for Alternative Anticoagulation in Extracorporeal Membrane Oxygenation: A Systematic Review
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Asmussen, Sven
Maybauer, Dirk, M.
Santonocito, Cristina
Fraser, John, F.
Erdoes, Gabor
Maybauer, Marc, O.
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Abstract
Extracorporeal membrane oxygenation (ECMO) offers therapeutic options in refractory respiratory and/or cardiac failure. Systemic anticoagulation with heparin is routinely administered. However, in patients with heparin-induced thrombocytopenia or heparin resistance, the direct thrombin inhibitor bivalirudin is a valid option and has been increasingly used for ECMO anticoagulation. We aimed at evaluating its safety and its optimal dosing for ECMO.
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Journal of Intensive Care Medicine
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32
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5
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Clinical sciences
Nursing
ECMO
HIT
cardiopulmonary bypass
direct thrombin inhibitor
heparin-induced thrombocytopenia
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Citation
Sanfilippo, F; Asmussen, S; Maybauer, DM; Santonocito, C; Fraser, JF; Erdoes, G; Maybauer, MO, Bivalirudin for Alternative Anticoagulation in Extracorporeal Membrane Oxygenation: A Systematic Review, Journal of Intensive Care Medicine, 2017, 32 (5), pp. 312-319