Nitrosative Stress as a Modulator of Inflammatory Change in a Model of Takotsubo Syndrome
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Nguyen, TH
Stafford, I
Chapman, M
Chacko, S
Singh, K
Licari, G
Raman, B
Kelly, DJ
Zhang, Y
Waddingham, MT
Ngo, DT
Bate, AP
Chua, SJ
et al.
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Abstract
Previous studies have shown that patients with Takotsubo syndrome (TS) have supranormal nitric oxide signaling, and post-mortem studies of TS heart samples revealed nitrosative stress. Therefore, we first showed in a female rat model that isoproterenol induces TS-like echocardiographic changes, evidence of nitrosative stress, and consequent activation of the energy-depleting enzyme poly(ADP-ribose) polymerase-1. We subsequently showed that pre-treatment with an inhibitor of poly(ADP-ribose) polymerase-1 ameliorated contractile abnormalities. These findings thus add to previous reports of aberrant β-adrenoceptor signaling (coupled with nitric oxide synthase activation) to elucidate mechanisms of impaired cardiac function in TS and point to potential methods of treatment.
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JACC: Basic to Translational Science
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3
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2
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© 2018 The Authors. Published by Elsevier on behalf of the American college of cardiology foundation.This is an open access article under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence (http://creativecommons.org/licenses/by-nc-nd/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
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Cardiovascular medicine and haematology
Clinical sciences
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Surikow, SY; Nguyen, TH; Stafford, I; Chapman, M; Chacko, S; Singh, K; Licari, G; Raman, B; Kelly, DJ; Zhang, Y; Waddingham, MT; Ngo, DT; Bate, AP; Chua, SJ; Frenneaux, MP; Horowitz, JD, Nitrosative Stress as a Modulator of Inflammatory Change in a Model of Takotsubo Syndrome, JACC: Basic to Translational Science, 2018, 3 (2), pp. 213-226