Reprogramming of human olfactory neurosphere-derived cells from olfactory mucosal biopsies of a control cohort
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Hunter, Z
Chaggar, HK
Mackay-Sim, A
Wolvetang, EJ
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Abstract
Human olfactory neurosphere-derived (ONS) cells are derived from the olfactory mucosa and display some progenitor- and neuronal cell-like properties, making them useful models of neurological disorders. However, they lack several important characteristics of true neurons, which can be overcome using induced pluripotent stem cell (iPSC) -derived neurons. Here we describe, for the first time, the generation and validation of an iPSC line from an olfactory biopsy from a control cohort member. This data lays the groundwork for future reprogramming of ONS cells, which can be used to generate neuronal models and compliment current ONS cell-based investigations into numerous neurological disorders.
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Stem Cell Research
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56
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© 2021 The Authors. Published by Elsevier B.V. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International (CC BY-NC-ND 4.0) License, which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
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Neurogenetics
Neurosciences
Regenerative medicine (incl. stem cells)
Biological sciences
Health sciences
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Leeson, HC; Hunter, Z; Chaggar, HK; Mackay-Sim, A; Wolvetang, EJ, Reprogramming of human olfactory neurosphere-derived cells from olfactory mucosal biopsies of a control cohort, Stem Cell Research, 2021, 56, pp. 102527-