Post-discharge pain management for paediatric patients is crucial for effective recovery, and parents require support to manage their child’s pain effectively at home. Aim The systematic review objective was to identify whether nurse-led telehealth follow-up is more effective than standard care (for example, outpatient follow-up) for managing pain in paediatric patients following hospital discharge. Methods The review was registered with Prospero (CRD42019123146) and was completed using the Joanna Briggs Institute (JBI) Systematic Review Method. A wide range of databases including CINAHL, Joanna Briggs Library, Cochrane Library, Scopus, ProQuest, PubMed and Science Direct were searched for quantitative studies involving nurse-led telehealth interventions for post-discharge follow-up of paediatric patients. The primary outcome was paediatric pain. Results Of the 1583 potentially relevant studies identified, and following title and abstract screening according to the inclusion criteria, 43 papers were selected for retrieval. Of these, 12 met the inclusion criteria. Quality assessment was completed using JBI MAStARI appraisal tools. Conclusion Evidence regarding the effectiveness of nurse-led telehealth follow-up for managing paediatric pain postdischarge is limited and existing research is of low to moderate strength. Existing studies suggest that nurse-led telephone follow-up can be a safe and potentially cost-effective practice. Further research is needed to explore the effectiveness of nurse-led telehealth in post-discharge paediatric pain management. This research should utilise valid and reliable measures of pain and parental satisfaction, and evaluate cost effectiveness and post-discharge healthcare utilisation.