Motor racing is a physically and mentally demanding sport, associated with a high degree of risk for drivers. Hence, driving simulation provides a safe alternative to explore the impact acute physiological perturbations (e.g. heat stress or dehydration) on a driver’s performance. This study aimed to determine sensitive and reliable simulated driving performance parameters that could be employed in future driving performance studies. Thirty-six healthy males (age: 26.5 ± 8.1 y, body mass: 75.6 ± 12.2 kg, mean ± SD) completed a single experimental trial involving four simulated motor-racing drives (2 initial drives and 2 repeat drives) separated by a 1 h period. Drives were conducted under two conditions, with one condition (wearing Fatal Vision Goggles (FVG)) designed to impair driving performance by distorting vision. Sensitivity was assessed by comparing Normal vs FVG outcomes and reliability was determined by comparing initial vs repeat drives for the same condition. Measures of driving performance included lap time (LT), sector-time (ST) for one section of the track, position displacement to a marker on the first track corner (PD), and vehicle Speed at PD. Results indicated that LT and ST were reliable and sensitive performance measures to a visual disturbance. However, PD was neither sensitive nor reliable and Speed at PD was not sensitive as driving performance measures to the study conditions. Overall, this study demonstrates two sensitive and reliable performance measures (LT and ST) that can be used to assess simulated motor-racing performance in future investigations.