The fields of art and science are closely intertwined within modern society, and they are capable of supporting and enhancing each other in various ways. For example, art is able to create and simulate inferred systems or processes that cannot be observed directly by any scientific method; the microscopic world of living cells is one biological system evading observation, as the sample preparation methods used in microscopy in most cases only allows viewing and imaging of already dead subjects. Being an artist working with liquid media, I realised that diffusion—a physical process involved in the dilution of paint in water and also forming the basis of the functioning of any cell—is not just a means of building visually stimulating artistic models of real-life microscopic processes but also a conceptual key that allows us to understand how art and science interact. The theoretical foundation of the methodology and subsequent discussion in this thesis is Gilles Deleuze and Félix Guattari’s theory of rhizome and its six major principles. The process of diffusion and its relationship with science and art are critical to my doctoral research. The importance of diffusion for living plant systems is viewed through a Deleuzian lens, using my practice-led outcomes to support and illustrate this approach. The ways that science can benefit from art in modern and contemporary context are examined through the work of other artists whose practices exist in the broad field where art and science overlap. I show that, for an artist, the transition between art and science can occur in both directions and how this transition relies on diffusion in their practice. The research reflects on my own art and science projects, outlining my involvement in microscopic studies of Australian nature, my work with Griffith University studying myrtle rust fungal disease in native Australian plants, and the discovery of aphids as a potential myrtle rust treatment. It provides insight into my diffusive practice as a trained artist and scientist, rhizomatically connected to the two different disciplines and to the microscopic world I study. The practice-led research outcomes are presented in different media, and they evidence that collaboration between art and science is capable of revealing the invisible forms of nature around us. This exegesis demonstrates that transdisciplinary collaboration has the potential for significant discoveries and that art offers another way to educate the public about urgent environmental problems.