Au(iii) compounds as HIV nucleocapsid protein (NCp7)–nucleic acid antagonists
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Mangrum, John B
Peterson, Erica J
Fabris, Daniele
Ptak, Roger
Farrell, Nicholas P
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Abstract
The HIV nucleocapsid NCp7-SL2 RNA interaction is interrupted in the presence of a formally substitution-inert gold(dien)-nucleobase/N-heterocycle AuN4 compound where the N-heterocycle serves the dual purposes of a template for "non-covalent" molecular recognition of the essential tryptophan of the protein, mimicking the natural reaction and subsequent "fixation" by Au-Cys bond formation providing a chemotype for a new distinct class of nucleocapsid-nucleic acid antagonist.
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Chemical Communications
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53
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1
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© 2016 The Authors. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal website for access to the definitive, published version.
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Chemical sciences
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Spell, SR; Mangrum, JB; Peterson, EJ; Fabris, D; Ptak, R; Farrell, NP, Au(iii) compounds as HIV nucleocapsid protein (NCp7)-nucleic acid antagonists., Chemical Communications, 2017, 53 (1), pp. 91-94