Characterisation of the Chemotaxis Signalling Pathway of Campylobacter Jejuni
File version
Author(s)
Primary Supervisor
Korolik, Victoria
Other Supervisors
Beacham, Ifor
Editor(s)
Date
Size
File type(s)
Location
License
Abstract
Campylobacter jejuni colonizes the intestinal mucosa of all food-producing animals and humans (Newell & Fearnley, 2003) and is the leading cause of human bacterial gastroenteritis worldwide (Blaser, 1997; Friedman et al., 2000). It is unclear exactly how C. jejuni induces disease outcome in humans, however, a number of factors have been implicated in the pathogenesis of this organism, including colonization and adherence, invasion and translocation, toxin production, LOS and capsule structures, flagella and motility, protein glycosylation and chemotaxis. Chemotactic behaviour has been demonstrated in C. jejuni (Hugdahl et al., 1988) and previous studies have shown the importance of chemotactic motility to the ability of C. jejuni to colonize and cause disease (Takata et al., 1992; Yao et al., 1997). However, the mechanisms controlling the C. jejuni chemotaxis signalling pathway remain largely unknown.
Journal Title
Conference Title
Book Title
Edition
Volume
Issue
Thesis Type
Thesis (PhD Doctorate)
Degree Program
Doctor of Philosophy (PhD)
School
Institute for Glycomics
Publisher link
Patent number
Funder(s)
Grant identifier(s)
Rights Statement
Rights Statement
The author owns the copyright in this thesis, unless stated otherwise.
Item Access Status
Public
Note
This thesis has been scanned. The published article included as pages 248-268 has not been published here for copyright reasons.
Access the data
Related item(s)
Subject
Campylobacter jejuni
Bacterial gastoenteritis
Chemotaxis