This article assesses general strain theory's (GST) primary mediator, anger, as a process that exhibits important variability across cultures. It presents data from structured interviews and fieldwork in India and the United States that suggest variations in the understanding and experience of anger across three samples: Americans, lay Tibetans, and Tibetan Buddhist clergy. Findings suggest cultural differences in normative social approval of anger, perceived effects for self of becoming angry, reaction tendencies, and emotional memory. Future research should test and map variations in anger across and within populations and explore implications for macro-level GST in explaining cross-cultural differences in crime.