This chapter maps the tensions between discourses of hegemonic masculinity and disability and details men’s agency in negotiating such tensions by drawing on six semi-structured interviews with men living with Lyme Disease (LD). This chronic illness renders men unable to perform the type of embodied masculinity they mobilized as able-bodied men via their participation in paid work, relationships, leisure and sport. As a consequence male interviewees look to new ways of constituting themselves as masculine tied to a different set of bodily practices and discourses such as via complementary and alternative medicine or through a focus on emotional literacy, care and communication.