Exploring the promise of flavonoids to combat neuropathic pain: From molecular mechanisms to therapeutic implications
File version
Version of Record (VoR)
Author(s)
Al Mamun, Abdullah
Rahman, Md Ataur
Kabir, Md Tanvir
Alkahtani, Saad
Alanazi, Ibtesam S
Perveen, Asma
Ashraf, Ghulam Md
Bin-Jumah, May N
Abdel-Daim, Mohamed M
Griffith University Author(s)
Primary Supervisor
Other Supervisors
Editor(s)
Date
Size
File type(s)
Location
Abstract
Neuropathic pain (NP) is the result of irregular processing in the central or peripheral nervous system, which is generally caused by neuronal injury. The management of NP represents a great challenge owing to its heterogeneous profile and the significant undesirable side effects of the frequently prescribed psychoactive agents, including benzodiazepines (BDZ). Currently, several established drugs including antidepressants, anticonvulsants, topical lidocaine, and opioids are used to treat NP, but they exert a wide range of adverse effects. To reduce the burden of adverse effects, we need to investigate alternative therapeutics for the management of NP. Flavonoids are the most common secondary metabolites of plants used in folkloric medicine as tranquilizers, and have been claimed to have a selective affinity to the BDZ binding site. Several studies in animal models have reported that flavonoids can reduce NP. In this paper, we emphasize the potentiality of flavonoids for the management of NP.
Journal Title
Frontiers in Neuroscience
Conference Title
Book Title
Edition
Volume
14
Issue
Thesis Type
Degree Program
School
Publisher link
Patent number
Funder(s)
Grant identifier(s)
Rights Statement
Rights Statement
© 2020 Uddin, Mamun, Rahman, Kabir, Alkahtani, Alanazi, Perveen, Ashraf, Bin-Jumah and Abdel-Daim. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Item Access Status
Note
Access the data
Related item(s)
Subject
Neurosciences
Clinical and health psychology
Cognitive and computational psychology
Biological psychology
Science & Technology
Life Sciences & Biomedicine
Neurosciences
Neurosciences & Neurology
neuropathic pain
Persistent link to this record
Citation
Uddin, MS; Al Mamun, A; Rahman, MA; Kabir, MT; Alkahtani, S; Alanazi, IS; Perveen, A; Ashraf, GM; Bin-Jumah, MN; Abdel-Daim, MM, Exploring the promise of flavonoids to combat neuropathic pain: From molecular mechanisms to therapeutic implications, Frontiers in Neuroscience, 2020, 14, pp. 478