Pestalactams A-C: Novel Caprolactams from the Endophytic Fungus Pestalotiopsis sp.
File version
Author(s)
Carroll, Anthony R
Andrews, Katherine T
Boyle, Glen M
Tran, Truc Linh
Healy, Peter C
Kalaitzis, John A
Shivas, Roger G
Griffith University Author(s)
Primary Supervisor
Other Supervisors
Editor(s)
Date
Size
250453 bytes
File type(s)
application/pdf
Location
License
Abstract
Chemical investigations of a fermentation culture from the endophytic fungus Pestalotiopsis sp. yielded three novel caprolactams, pestalactams A-C (1-3). The structures of 1-3 were determined by analysis of 1D and 2D-NMR, UV, IR, and MS data. The structure of pestalactam A was confirmed following single crystal X-ray diffraction analysis. Pestalactams A-C are the first C-7 alkylated caprolactam natural products to be reported. Pestalactams A (1) and B (2) were tested against two different strains of the malaria parasite Plasmodium falciparum (3D7 and Dd2), and the mammalian cell lines, MCF-7 and NFF, and showed modest in vitro activity in all assays.
Journal Title
Organic & Biomolecular Chemistry
Conference Title
Book Title
Edition
Volume
8
Issue
8
Thesis Type
Degree Program
School
Publisher link
DOI
Patent number
Funder(s)
Grant identifier(s)
Rights Statement
Rights Statement
© 2010 Royal Society of Chemistry. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal website for access to the definitive, published version.
Item Access Status
Note
Access the data
Related item(s)
Subject
Medicinal and biomolecular chemistry
Organic chemistry
Natural products and bioactive compounds