Weight gain and obesity are significant public health problems. Weight gain results from a shift in energy balance, when an individual consumes more energy than required for their given energy expenditure. As such, health professionals, scientists, and governing bodies are striving to find effective interventions that will return the energy balance equation to neutral levels, or manipulate the equation in a negative direction to induce weight loss. Physiological manipulations, such as exercise, are inexpensive and effective at influencing energy balance. Pharmacological and dietary strategies, such as caffeine and coffee, have been less examined. Exercise, coffee, and caffeine are relatively prevalent in modern societies. Therefore, improving our understanding of how these manipulations interact with respect to factors influencing energy balance is of high importance. This thesis comprises a series of studies that aim to examine the influence of exercise, nutritional (coffee/caffeine) manipulations, and their combination, on factors that influence energy balance. The specific aims are to 1) determine how acute exercise influences subsequent energy intake over a period of less than 24 h; 2) determine how acute exercise influences hormones related to appetite (acylated ghrelin, peptide YY, pancreatic polypeptide, and glucagon-like peptide-1) and whether these hormonal changes relate to post-exercise alterations in energy intake; 3) examine how caffeine and/or coffee influence appetite, gastric emptying, and energy intake; and 4) determine how caffeine consumed before and after a bout of exercise influences acute energy balance.