Generation of a Novel Multiphasic Bone-Ligament-Bone Construct for Scapholunate Interosseous Ligament Reconstruction
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Tedman, Raymond
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Bindra, Randipsingh
Vaquette, Cedryck
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Abstract
Background: Scapholunate interosseous ligament (SLIL) tears are a common wrist injury in young and active patients with suboptimal outcomes after surgical repair. While bone-ligament-bone (BLB) constructs have been successfully developed in orthopaedics for the replacement of damaged anterior cruciate ligaments (ACL), this has not been applied for the reconstruction of small joints. This novel approach could potentially be superior to equivalent autografts due to factors including: (1) Replication of the patient's SLIL external morphology allowing for identical matching of construct to existing joint architecture (2) Maintenance of equivalent biomechanical properties as the native SLIL (3) Incorporation of biochemical cues to promote vascularisation and tissue regeneration thereby minimising overall healing time and (4) Elimination of donor morbidity when harvesting autografts. Study Aim: The overarching aim of this thesis is to produce an artificial construct with a BLB interface for subsequent implantation into small joints. To this end, additive manufacturing was utilised to create a novel composite bioscaffold suitable for dorsal SLIL replacement in the wrist. [...]
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Thesis (PhD Doctorate)
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Doctor of Philosophy (PhD)
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School of Medicine
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The author owns the copyright in this thesis, unless stated otherwise.
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Subject
Scapholunate interosseous ligament
SLIL
bone-ligament-bone
BLB
wrist ligament injuries