Generation of a Novel Multiphasic Bone-Ligament-Bone Construct for Scapholunate Interosseous Ligament Reconstruction

Loading...
Thumbnail Image
File version
Primary Supervisor

Tedman, Raymond

Other Supervisors

Bindra, Randipsingh

Vaquette, Cedryck

Editor(s)
Date
2019
Size
File type(s)
Location
License
Abstract

Background: Scapholunate interosseous ligament (SLIL) tears are a common wrist injury in young and active patients with suboptimal outcomes after surgical repair. While bone-ligament-bone (BLB) constructs have been successfully developed in orthopaedics for the replacement of damaged anterior cruciate ligaments (ACL), this has not been applied for the reconstruction of small joints. This novel approach could potentially be superior to equivalent autografts due to factors including: (1) Replication of the patient's SLIL external morphology allowing for identical matching of construct to existing joint architecture (2) Maintenance of equivalent biomechanical properties as the native SLIL (3) Incorporation of biochemical cues to promote vascularisation and tissue regeneration thereby minimising overall healing time and (4) Elimination of donor morbidity when harvesting autografts. Study Aim: The overarching aim of this thesis is to produce an artificial construct with a BLB interface for subsequent implantation into small joints. To this end, additive manufacturing was utilised to create a novel composite bioscaffold suitable for dorsal SLIL replacement in the wrist. [...]

Journal Title
Conference Title
Book Title
Edition
Volume
Issue
Thesis Type

Thesis (PhD Doctorate)

Degree Program

Doctor of Philosophy (PhD)

School

School of Medicine

Publisher link
Patent number
Funder(s)
Grant identifier(s)
Rights Statement
Rights Statement

The author owns the copyright in this thesis, unless stated otherwise.

Item Access Status
Note
Access the data
Related item(s)
Subject

Scapholunate interosseous ligament

SLIL

bone-ligament-bone

BLB

wrist ligament injuries

Persistent link to this record
Citation