Organic NIR-II molecule with long blood half-life for in vivo dynamic vascular imaging

Loading...
Thumbnail Image
File version
Version of Record (VoR)
Author(s)
Li, B
Zhao, M
Feng, L
Dou, C
Ding, S
Zhou, G
Lu, L
Zhang, H
Chen, F
Li, X
Li, G
Zhao, S
Jiang, C
Zhao, D
et al.
Griffith University Author(s)
Primary Supervisor
Other Supervisors
Editor(s)
Date
2020
Size
File type(s)
Location
License
http://creativecommons.org/licenses/by/4.0/
Abstract

Real-time monitoring of vessel dysfunction is of great significance in preclinical research. Optical bioimaging in the second near-infrared (NIR-II) window provides advantages including high resolution and fast feedback. However, the reported molecular dyes are hampered by limited blood circulation time (~ 5–60 min) and short absorption and emission wavelength, which impede the accurate long-term monitoring. Here, we report a NIR-II molecule (LZ-1105) with absorption and emission beyond 1000 nm. Thanks to the long blood circulation time (half-life of 3.2 h), the fluorophore is used for continuous real-time monitoring of dynamic vascular processes, including ischemic reperfusion in hindlimbs, thrombolysis in carotid artery and opening and recovery of the blood brain barrier (BBB). LZ-1105 provides an approach for researchers to assess vessel dysfunction due to the long excitation and emission wavelength and long-term blood circulation properties.

Journal Title
Nature Communications
Conference Title
Book Title
Edition
Volume
11
Issue
1
Thesis Type
Degree Program
School
Publisher link
Patent number
Funder(s)
Grant identifier(s)
Rights Statement
Rights Statement
© The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Item Access Status
Note
Access the data
Related item(s)
Subject
Nanotechnology
Persistent link to this record
Citation
Li, B; Zhao, M; Feng, L; Dou, C; Ding, S; Zhou, G; Lu, L; Zhang, H; Chen, F; Li, X; Li, G; Zhao, S; Jiang, C; Zhao, D; et al., Organic NIR-II molecule with long blood half-life for in vivo dynamic vascular imaging, Nature Communications, 2020, 11 (1), pp. 3102
Collections