Prediction and prevention of preeclampsia

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Peixoto-Filho, Fernando Maia
Costa, Fabricio da Silva
Kobayashi, Sergio
Beitune, Patricia El
Garrido, Adriana Gualda
Carmo, Anselmo Verlangieri
Rezende, Guilherme de Castro
Junior, Heron Werner
Junior, Joffre Amin
Leao, Jorge Roberto Di Tommaso
Nardozza, Luciano Marcondes Machado
Machado, Luiz Eduardo
Sarno, Manoel Alfredo Curvelo
Neto, Pedro Pires Ferreira
Junior, Eduardo Becker
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2023
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Abstract

Keypoints: Preeclampsia (PE) is an important cause of maternal and perinatal mortality worldwide, accounts for 10% to 15% of direct maternal deaths, and 99% of these deaths are in low-income countries. Preeclampsia is defined as systolic blood pressure of ≥140 mmHg and/or diastolic blood pressure of ≥90 mmHg on at least two occasions, measured four hours apart in previously normotensive women, and is accompanied by one or more of the following new-onset conditions after 20 weeks' gestation: (1) proteinuria, (2) evidence of other maternal organ dysfunction, or (3) uteroplacental dysfunction. Preeclampsia is classified into: (1) early PE (delivery < 34+0 weeks' gestation); (2) preterm PE (delivery < 37+0 weeks' gestation); (3) late-onset PE (delivery ≥ 34+0 weeks' gestation); (4) term PE (delivery ≥ 37+0 weeks' gestation). In Brazil, the incidence of PE varies from 1.5% to 7%; of preterm PE is 2% and of eclampsia is 0.6%. However, these statistics are likely to be underestimated and vary according to the region studied. Screening strategies for PE vary depending on the parameters used, pre-test risk, outcome stratification, and the gestational age at which screening is performed. However, there is consensus in the literature that no single-parameter screening test has been shown to adjust the preexisting maternal risk for PE with sufficient specificity and sensitivity for clinical use.

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Revista Brasileira de Ginecologia e Obstetrícia

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45

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1

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© 2023. Federação Brasileira de Ginecologia e Obstetrícia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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Obstetrics and gynaecology

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Life Sciences & Biomedicine

UTERINE ARTERY DOPPLER

SERUM PAPP-A

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Peixoto-Filho, FM; Costa, FDS; Kobayashi, S; Beitune, PE; Garrido, AG; Carmo, AV; Rezende, GDC; Junior, HW; Junior, JA; Leao, JRDT; Nardozza, LMM; Machado, LE; Sarno, MAC; Neto, PPF; Junior, EB, Prediction and prevention of preeclampsia, Revista Brasileira de Ginecologia e Obstetrícia, 2023, 45 (1), pp. 49-54

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