Purpose of Review: The purpose of this paper is to provide a current review of the recent literature (2015–2018) on psychophysiological markers of fear and anxiety. Recent Finding: Relative to healthy controls, fear-based disorders are characterised by heightened physiological reactivity to circumscribe threat salient stimuli, whereas anxiety-related disorders are associated with a more blunted pattern of physiological reactivity. Summary: Fear and anxiety disorders are marked by abnormal patterns of physiological reactivity, characterised by hyper- and hypo-reactivity in response to stimuli varying in threat salience.