Accurate prediction of the propagation pressure (PP) in hybrid steel-CFRP pipe systems presents a substantial challenge due to intricate interactions and complex collapse failure modes. An efficient FE-based algorithm is programmed using ANSYS to numerically estimate the PP of hybrid steel-CFRP pipe, subjected to external pressure. This study employs a machine learning (ML) framework, addressing the inherent complexity with a three-phase approach: Parameter Design, Buckle Propagation Analysis, and ML Model Development. The dataset, encompassing about two thousand observations with four key features, undergoes k-fold cross-validation and min-max normalization for robust ML performance. Five ML models—Random Forest (RF), K-Nearest Neighbors (KNN), Genetic Programming (GP), Multi-layer Perceptron (MLP), and Support Vector Machine (SVM)—are developed and evaluated. The results revealed a significant influence of Ds/ts, a three-phase relationship with ts/tc, and a substantial decrease in PPh/PPs with increasing σys/σuc, predominantly exhibiting U-shaped or dog-bone failure modes in different scenarios. Proven that GP, KNN, and RF are the superior performers, ranking ahead of SVM with Gaussian Kernel (SVM-GK), MLP, and SVM with Linear Kernel (SVM-LK). Statistical metrics, Taylor Diagram analysis, and comparisons with FE results emphasize the effectiveness of GP, KNN, and RF. Additionally, normality tests and feature importance analysis provide nuanced insights.