Objective: This study describes the peri-operative results, safety, and functional outcomes of transurethral resection of the prostate (TURP) performed in men with benign prostatic hyperplasia [or hypertrophy; (BPH)] and a prostate gland volume ≥100 cc. Materials and Methods: A retrospective analysis of a cohort of patients undergoing TURP at a single institution over four years was undertaken. Patients with known prostate cancer were excluded. Clinical outcomes were between men with a prostate volume of ≥100 cc and men with a prostate volume <100 cc. Functional outcomes were assessed by defining a series of measurable post-operative “lower urinary tract symptoms (LUTS) events” and comparing the time-to-event profile using a Kaplan-Meier estimator. Results: Out of a total of 238 men who underwent TURP for BPH during the study period, 72 had a prostate volume ≥100 cc (30%). Baseline demographics were similar to the group of patients with a prostate volume <100 cc. Patients with large prostates had a significantly longer mean operating time (56 vs 98 minutes, p<0.0001). The peri-operative complication profile and post-operative complication rate were similar between the two groups. During a median follow-up period of 27 months (range, 2-54 months), no difference in LUTS events-free survival was observed (p=0.93). Conclusion: Our results show that TURP can be safely performed in patients with large prostate glands (≥100 cc). Although operating times were longer in the large prostate group, this did not significantly affect the complication rate nor compromise a good functional outcome.