Efficient Blocking of Enterovirus 71 Infection by Heparan Sulfate Analogues Acting as Decoy Receptors

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Earley, Daniel F
Bailly, Benjamin
Maggioni, Andrea
Kundur, Avinash R
Thomson, Robin J
Chang, Chih-Wei
von Itzstein, Mark
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2019
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Abstract

Enterovirus 71 (EV71) is a major etiological agent of hand, foot, and mouth disease, for which there is no antiviral therapy. We have developed densely sulfated disaccharide heparan sulfate (HS) analogues that are potent small molecule inhibitors of EV71 infection, binding to the viral capsid and acting as decoy receptors to block early events of virus replication. The simplified structures, more potent than defined HS disaccharides and with no significant anticoagulant activity, offer promise as anti-EV71 agents.

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ACS Infectious Diseases

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5

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10

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Medical microbiology

Science & Technology

Life Sciences & Biomedicine

Chemistry, Medicinal

Infectious Diseases

Pharmacology & Pharmacy

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Earley, DF; Bailly, B; Maggioni, A; Kundur, AR; Thomson, RJ; Chang, C-W; von Itzstein, M, Efficient Blocking of Enterovirus 71 Infection by Heparan Sulfate Analogues Acting as Decoy Receptors, ACS Infectious Diseases, 2019, 5 (10), pp. 1708-1717

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