Aplysamine 6, an Alkaloidal Inhibitor of Isoprenylcysteine Carboxyl Methyltransferase from the Sponge Pseudoceratina sp.

No Thumbnail Available
File version
Author(s)
Buchanan, Malcolm S
Carroll, Anthony R
Fechner, Gregory A
Boyle, Anthony
Simpson, Moana
Addepalli, Rama
Avery, Vicky M
Hooper, John NA
Cheung, Tony
Chen, Huwei
Quinn, Ronald J
Primary Supervisor
Other Supervisors
Editor(s)

A Kinghorn Douglas

Date
2008
Size
File type(s)
Location
License
Abstract

The anticancer target isoprenylcysteine carboxyl methyltransferase (Icmt) was the focus of a natural product high-throughput screening campaign. The Australian marine sponge Pseudoceratina sp. yielded aplysamine 6, a new bromotyrosine derivative with an a,߭unsaturated amide linkage, as the bioactive constituent. Its structure was determined by 1D and 2D NMR spectroscopy.

Journal Title

Journal of Natural Products

Conference Title
Book Title
Edition
Volume

71

Issue

6

Thesis Type
Degree Program
School
Patent number
Funder(s)
Grant identifier(s)
Rights Statement
Rights Statement

© 2008 American Chemical Society. Self-archiving of the author-manuscript version is not yet supported by this publisher. Please refer to the journal link for access to the definitive, published version or contact the authors for more information.

Item Access Status
Note
Access the data
Related item(s)
Subject

Chemical sciences

Biological sciences

Biomedical and clinical sciences

Traditional, complementary and integrative medicine

Persistent link to this record
Citation
Collections