Human milk oligosaccharide 2′-fucosyllactose guards norovirus histo-blood group antigen co-factor binding site
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Kher, Gargi
Tame, Jeremy RH
Irie, Hiro
Haselhorst, Thomas
von Itzstein, Mark
Pancera, Marie
Hansman, Grant S
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Wobus, Christiane E
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Abstract
Histo-blood group antigens (HBGAs) are critical polymorphic glycan co-factors required for most norovirus infections (1, 2). However, human milk oligosaccharide (HMO) 2’-fucosyllactose (2’-FL), a component of human breast milk and made up of related glycan saccharides, also binds to norovirus at the HBGA pocket as we have previously discovered (3, 4). We have also shown that 2’-FL weakly inhibits norovirus virus-like particles (VLPs) from attaching to HBGAs for genetically distinct noroviruses GI.1, GII.10, and GII.17 (3, 4).
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Journal of Virology
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98
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7
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Medical virology
Agricultural, veterinary and food sciences
Biological sciences
Biomedical and clinical sciences
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Rudd, PA; Kher, G; Tame, JRH; Irie, H; Haselhorst, T; von Itzstein, M; Pancera, M; Hansman, GS, Human milk oligosaccharide 2′-fucosyllactose guards norovirus histo-blood group antigen co-factor binding site, Journal of Virology, 2024