Stochastic Electrochemical Measurement of a Biofouling Layer on Gold
File version
Author(s)
Somerville, Samuel V
Dief, Essam M
Gooding, J Justin
Griffith University Author(s)
Primary Supervisor
Other Supervisors
Editor(s)
Date
Size
File type(s)
Location
License
Abstract
Adsorption of a biofouling layer on the surface of biosensors decreases the electrochemical activity and hence shortens the service life of biosensors, particularly implantable and wearable biosensors. Real-time quantification of the loss of activity is important for in situ assessment of performance while presenting an opportunity to compensate for the loss of activity and recalibrate the sensor to extend the service life. Here, we introduce an electrochemical noise measurement technique as a tool for the quantification of the formation of a biofouling layer on the surface of gold. The technique uniquely affords thermodynamic and kinetic information without applying an external bias (potential and/or current), hence allowing the system to be appraised in its innate state. The technique relies on the analysis of non-faradaic current and potential fluctuations that are intrinsically generated by the interaction of charged species at the electrode surface, i.e., gold. An analytical model is extended to explain the significance of parameters drawn from statistical analysis of the noise signal. This concept is then examined in buffered media in the presence of albumin, a common protein in the blood and a known source of a fouling layer in biological systems. Results indicate that the statistical analysis of the noise signal can quantify the loss of electrochemical activity, which is also corroborated by impedance spectroscopy as a complementary technique.
Journal Title
Analytical Chemistry
Conference Title
Book Title
Edition
Volume
96
Issue
19
Thesis Type
Degree Program
School
Publisher link
Patent number
Funder(s)
ARC
Grant identifier(s)
DE210101137
Rights Statement
Rights Statement
Item Access Status
Note
Access the data
Related item(s)
Subject
Medical biochemistry and metabolomics
Analytical chemistry
Chemical engineering
Persistent link to this record
Citation
Jamali, SS; Somerville, SV; Dief, EM; Gooding, JJ, Stochastic Electrochemical Measurement of a Biofouling Layer on Gold, Analytical Chemistry, 2024, 96 (19), pp. 7401-7410