Public health implications of SARS-CoV-2 variants of concern: a rapid scoping review
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Curran, Janet A
Dol, Justine
Boulos, Leah
Saxinger, Lynora
Doroshenko, Alexander
Hastings, Stephanie
Reynolds, Bearach
Gallant, Allyson J
Shin, Hwayeon Danielle
Wong, Helen
Crowther, Daniel
Macdonald, Marilyn
Martin-Misener, Ruth
Comeau, Jeannette
et al.
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OBJECTIVES: The four SARS-CoV-2 variants of concern (VOC; Alpha, Beta, Gamma and Delta) identified by May 2021 are highly transmissible, yet little is known about their impact on public health measures. We aimed to synthesise evidence related to public health measures and VOC. DESIGN: A rapid scoping review. DATA SOURCES: On 11 May 2021, seven databases (MEDLINE, Embase, the Cochrane Database of Systematic Reviews, Central Register of Controlled Trials, Epistemonikos' L-OVE on COVID-19, medRxiv, bioRxiv) were searched for terms related to VOC, public health measures, transmission and health systems. No limit was placed on date of publication. ELIGIBILITY CRITERIA: Studies were included if they reported on any of the four VOCs and public health measures, and were available in English. Only studies reporting on data collected after October 2020, when the first VOC was reported, were included. DATA EXTRACTION AND SYNTHESIS: Titles, abstracts and full-text articles were screened by two independent reviewers. Data extraction was completed by two independent reviewers using a standardised form. Data synthesis and reporting followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews guidelines. RESULTS: Of the 37 included studies, the majority assessed the impact of Alpha (n=32) and were conducted in Europe (n=12) or the UK (n=9). Most were modelling studies (n=28) and preprints (n=28). The majority of studies reported on infection control measures (n=17), followed by modifying approaches to vaccines (n=13), physical distancing (n=6) and either mask wearing, testing or hand washing (n=2). Findings suggest an accelerated vaccine rollout is needed to mitigate the spread of VOC. CONCLUSIONS: The increased severity of VOC requires proactive public health measures to control their spread. Further research is needed to strengthen the evidence for continued implementation of public health measures in conjunction with vaccine rollout. With no studies reporting on Delta, there is a need for further research on this and other emerging VOC on public health measures.
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BMJ Open
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11
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12
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© Author(s) (or their employer(s)) 2021. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
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Clinical sciences
COVID-19
health policy
public health
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Somerville, M; Curran, JA; Dol, J; Boulos, L; Saxinger, L; Doroshenko, A; Hastings, S; Reynolds, B; Gallant, AJ; Shin, HD; Wong, H; Crowther, D; Macdonald, M; Martin-Misener, R; Comeau, J; et al., Public health implications of SARS-CoV-2 variants of concern: a rapid scoping review., BMJ Open, 2021, 11 (12), pp. e055781-