Investigation of the potential of a novel 48 kDa protein as a vaccine candidate for infection against nontypable Haemophilus influenzae
File version
Author(s)
Otczyk, Diana C
Cripps, Allan W
Griffith University Author(s)
Primary Supervisor
Other Supervisors
Editor(s)
Date
Size
1159741 bytes
File type(s)
application/pdf
Location
License
Abstract
This study determined the conservation and protective efficacy of a 48 kDa nontypable Haemophilus influenzae (NTHi) protein (P48). This protein was highly conserved across the strains of NTHi examined and mucosal immunization with recombinant P48 (rP48) significantly reduced the numbers of viable NTHi recovered from the lung following challenge. rP48 induced predominantly an IgG2a antibody response that correlated with the reduction in the number of viable NTHi in the lung. These antibodies were not bactericidal against NTHi. The results suggest that P48 warrants further investigation as a vaccine component for NTHi disease.
Journal Title
Vaccine
Conference Title
Book Title
Edition
Volume
25
Issue
Thesis Type
Degree Program
School
Patent number
Funder(s)
Grant identifier(s)
Rights Statement
Rights Statement
© 2007 Elsevier. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
Item Access Status
Note
Access the data
Related item(s)
Subject
Biological sciences
Agricultural, veterinary and food sciences
Biomedical and clinical sciences