Association between timing of diagnosis of trisomy 21, 18, and 13 and maternal socio-economic status in Victoria, Australia: A population-based cohort study from 2015 to 2016
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Halliday, Jane
Poulton, Alice
Lindquist, Anthea
Hutchinson, Briohny
Bethune, Michael
Bonacquisto, Leonard
Da Silva Costa, Fabricio
Gugasyan, Lucy
Harraway, James
Howden, Amanda
Kulkarni, Abhijit
Martin, Nicole
McCoy, Richard
Menezes, Melody
et al.
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Abstract
Objectives: To explore the association between timing of diagnosis of common autosomal trisomies, maternal age, and socio-economic status (SES). Design: Retrospective study of cytogenetic diagnoses of trisomy 21 (T21), trisomy 18 (T18), and trisomy 13 (T13) in Victoria, Australia, in 2015 to 2016, stratified by timing (prenatal less than 17 weeks gestation, prenatal including or greater than or 17 weeks gestation, and postnatal before 12 months of age), maternal age, and SES region. Utilisation of prenatal testing following a live-born T21 infant was ascertained via record linkage. Results: Among 160 230 total births were 571 diagnoses of T21 and 246 of T18/T13. The overall and live birth prevalences of T21 were 3.56 and 0.47 per 1000 births, respectively. Compared with women from disadvantaged SES regions, women from high SES regions were more likely to have a prenatal diagnosis of a trisomy before 17 weeks than after (P <.01) and less likely to have a live-born T21 infant than a prenatal diagnosis (P <.01). There was a significant trend to higher live birth rates of T21 with lower SES (P =.004). The majority (68.5%) of women who gave birth to a live infant with T21 did not utilise prenatal testing. Conclusion: There is a significant relationship between lower SES, later prenatal diagnosis of trisomy, and higher live birth rate of T21 in Victoria.
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Prenatal Diagnosis
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39
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13
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© 2019 John Wiley & Sons, Ltd. This is the peer reviewed version of the following article: Association between timing of diagnosis of trisomy 21, 18, and 13 and maternal socio-economic status in Victoria, Australia: A population-based cohort study from 2015 to 2016, Prenatal Diagnosis, 2019, 39 (13), pp. 1254-1261, which has been published in final form at https://doi.org/10.1002/pd.5577. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.
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Clinical sciences
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Life Sciences & Biomedicine
Genetics & Heredity
Obstetrics & Gynecology
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Kluckow, E; Halliday, J; Poulton, A; Lindquist, A; Hutchinson, B; Bethune, M; Bonacquisto, L; Da Silva Costa, F; Gugasyan, L; Harraway, J; Howden, A; Kulkarni, A; Martin, N; McCoy, R; Menezes, M; et al., Association between timing of diagnosis of trisomy 21, 18, and 13 and maternal socio-economic status in Victoria, Australia: A population-based cohort study from 2015 to 2016, Prenatal Diagnosis, 2019, 39 (13), pp. 1254-1261