Exploring potential of alkaloidal phytochemicals targeting neuroinflammatory signaling of Alzheimer's disease

No Thumbnail Available
File version
Author(s)
Uddin, Md Sahab
Kabir, Md Tanvir
Al Mamun, Abdullah
Behl, Tapan
Mansouri, Rasha A
Aloqbi, Akram Ahmed
Perveen, Asma
Hafeez, Abdul
Ashraf, Ghulam Md
Griffith University Author(s)
Primary Supervisor
Other Supervisors
Editor(s)
Date
2021
Size
File type(s)
Location
License
Abstract

Alzheimer's disease (AD) is a chronic neurodegenerative disorder that is marked by cognitive dysfunctions and the existence of neuropathological hallmarks such as amyloid plaques, and neurofibrillary tangles. It has been observed that a persistent immune response in the brain has appeared as another neuropathological hallmark in AD. The sustained activation of the microglia, the brain’s resident macrophages, and other immune cells has been shown to aggravate both tau and amyloid pathology and may consider as a connection in the AD pathogene-sis. However, the basic mechanisms that link immune responses in the pathogenesis of AD are unclear until now since the process of neuroinflammation can have either a harmful or favorable effect on AD, according to the phase of the disease. Numerous researches recommend that nutritional fruits, as well as vegetables, possess neurodefensive properties against the detrimental effects of neuroinflammation and aging. Moreover, these effects are controlled by diverse phytochemical compounds that are found in plants and demonstrate anti-inflammatory, neuroprotective, as well as other beneficial actions. In this review, we focus on the link of neuroinflammation in AD as well as highlight the probable mechanisms of alkaloidal phytochemicals to combat the neuroinflammatory aspect of AD.

Journal Title

Current Pharmaceutical Design

Conference Title
Book Title
Edition
Volume

27

Issue

3

Thesis Type
Degree Program
School
Publisher link
Patent number
Funder(s)
Grant identifier(s)
Rights Statement
Rights Statement
Item Access Status
Note
Access the data
Related item(s)
Subject

Pharmacology and pharmaceutical sciences

Science & Technology

Life Sciences & Biomedicine

Pharmacology & Pharmacy

Alzheimer's disease

amyloid plaques

Persistent link to this record
Citation

Uddin, MS; Kabir, MT; Al Mamun, A; Behl, T; Mansouri, RA; Aloqbi, AA; Perveen, A; Hafeez, A; Ashraf, GM, Exploring potential of alkaloidal phytochemicals targeting neuroinflammatory signaling of Alzheimer's disease, Current Pharmaceutical Design, 2021, 27 (3), pp. 357-366

Collections