The Gold Coast will host the 21st Commonwealth Games from 4–15 April 2018. This is the Gold Coast’s first experience in hosting a mega-event, which means there is a knowledge gap about how the business community can benefit. Understanding the key macro factors surrounding the Gold Coast 2018 Commonwealth Games (GC2018) is crucial for the Gold Coast business community, especially for those operating small and medium private enterprises. There will inevitably be disruption confronting business as a consequence of GC2018, but as the detailed analysis in this report makes clear, the scope for the Gold Coast business community to leverage opportunities from GC2018 is tangible and significant. Based on interviews and a review of previous studies of major sporting mega-events, this report assesses the impact and legacy of GC2018. Most importantly, it outlines a roadmap for Gold Coast businesses to take advantage of the once-in-a-generation opportunities that will flow from the Games.