The case for agile leadership and responsive innovation in Australian Initial Teacher Education (ITE) through ensuing a three-stage process: reform, renew, and reflect was investigated in this case study. As such, the paper is organised under these three areas. Explicit links between the literature and the mandate for reform is presented. A case study approach then delineates the response to national and local imperatives framed as an opportunity for curriculum renewal. The case study presents the actions enacted to bring about innovative change. This investigation makes a significant contribution by accentuating the inhibitors and enablers encountered during a process of renewal and making a call for agile leadership and responsive innovation at this time of reform.