Pim2 Inhibitors from the Papua New Guinean Plant Cupaniopsis macropetala
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Author(s)
Simpson, Moana M
Nugent, Ryan B
Carroll, Anthony R
Avery, Vicky M
Rali, Topul
Chen, Huawei
Qurallo, Barbara
Quinn, Ronald J
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Kinghorn, Douglas A.
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Abstract
Bioassay-guided fractionation of an organic extract from the leaves of Cupaniopsis macropetala resulted in the isolation of a new alkaloid, galloyl tyramine (1), together with the known flavonoid glycoside quercitrin (2). The structure of 1 was determined following 1D and 2D NMR, IR, UV, and MS data analysis. Compounds 1 and 2 displayed IC50 values of 161 and 25 卬 respectively, in a Pim2 enzyme assay.
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Journal of Natural Products
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71
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3
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© 2008 American Chemical Society. Self-archiving of the author-manuscript version is not yet supported by this publisher. Please refer to the journal link for access to the definitive, published version or contact the authors for more information.
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Chemical sciences
Biological sciences
Biomedical and clinical sciences
Traditional, complementary and integrative medicine